MIA40 / CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

MIA40 / CHCHD4 (5)

Publications

No (5)

Tag

GST (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human MIA40 / CHCHD4 Protein (Recombinant His-SUMO) (Full Length) - LS-G21869

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

32 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MIA40 / CHCHD4 Protein (Recombinant GST) (Full Length) - LS-G36484

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

42.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MIA40 / CHCHD4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72821

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

15.8 kDa

Price:

20 µg/$1,107

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Human MIA40 / CHCHD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93657

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

15.8 kDa

Price:

20 µg/$150

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MIA40 / CHCHD4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119229

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

15.8 kDa

Price:

100 µg/$494

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