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MIA40 / CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system.
| Gene Name: | coiled-coil-helix-coiled-coil-helix domain containing 4 |
| Synonyms: | CHCHD4, CHDH4, TIMM40, MIA40 |
| Target Sequences: | Q8N4Q1 Q8N4Q1 |
Publications (1)
1
Rapid enrichment of mitochondria from mammalian cell cultures using digitonin. Bhavna Dixit, Shon Vanhoozer, Nana Abena Anti, Matthew S O'Connor, Amutha Boominathan. MethodsX. 2020 Dec;8:101197. [Full Text Article]
[PubMed:34434723]
[PMC:PMC8374178]
Related Antibodies: LS-C802857.
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Antibodies
(21)
Type
Primary
(21)
Target
MIA40 / CHCHD4
(21)
Reactivity
Human
(21)
Mouse
(6)
Rat
(5)
Chicken
(3)
Chimpanzee
(3)
Gibbon
(3)
Guinea pig
(3)
Xenopus
(3)
Application
IHC
(12)
IHC-P
(6)
WB
(14)
ELISA
(10)
IF
(1)
IP
(2)
Peptide-ELISA
(1)
Host
rabbit
(21)
Isotype
IgG
(20)
Clonality
polyclonal pc
(21)
Format
APC Conjugated
(1)
Azide-free
(1)
Biotin Conjugated
(3)
FITC Conjugated
(3)
HRP Conjugated
(3)
PE Conjugated
(1)
Preservative Free
(1)
Unconjugated
(10)
Epitope
aa101-129
(7)
N-Terminus
(4)
aa1-142
(4)
aa92-142
(2)
Publications
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(20)
Yes
(1)
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa1-142) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa1-142) (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa1-142) (Biotin) Antibody
Human
ELISA, IHC, IHC-P
Biotin Conjugated
50 µg/$294; 100 µg/$360
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa1-142) (FITC) Antibody
Human
ELISA, IHC, IHC-P
FITC Conjugated
50 µg/$294; 100 µg/$360
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa101-129) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa101-129) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa101-129) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa101-129) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa101-129) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa101-129) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa101-129) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
MIA40 / CHCHD4 Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse, Rat, Human
IHC-P
Unconjugated, Preservative Free
100 µl/$412
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa92-142) Antibody
Human
IP, WB
Unconjugated
10 µl/$295
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Xenopus, Chicken, Mouse, Guinea pig, Rat, Chimpanzee, Gibbon, Human
WB
HRP Conjugated
100 µl/$469
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Chicken, Mouse, Guinea pig, Rat, Chimpanzee, Gibbon, Human
WB
Biotin Conjugated
100 µl/$469
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Chicken, Mouse, Guinea pig, Rat, Chimpanzee, Gibbon, Human
WB
FITC Conjugated
100 µl/$469
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal Antibody
Human
Unconjugated
100 µg/$331
MIA40 / CHCHD4 Rabbit anti-Human Polyclonal (aa92-142) Antibody
Human
IP
Unconjugated
10 µl/$295
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