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MIA40 / CHCHD4
coiled-coil-helix-coiled-coil-helix domain containing 4
Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system.
| Gene Name: | coiled-coil-helix-coiled-coil-helix domain containing 4 |
| Synonyms: | CHCHD4, CHDH4, TIMM40, MIA40 |
| Target Sequences: | Q8N4Q1 Q8N4Q1 |
Publications (1)
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