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Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.
Gene Name: | MGA, MAX dimerization protein |
Synonyms: | MGA, KIAA0518, MAD5, MAX gene associated, MAX gene-associated protein, MGA, MAX dimerization protein, MXD5, MAX dimerization protein 5 |
Target Sequences: | AB011090 BAA25444.1 Q8IWI9 |
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