Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
Products
Antibodies
ELISA and Assay Kits
Research Areas
Infectious Disease
Resources
Purchasing
Reference Material
Contact Us
Location
Corporate Headquarters
Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
Telephone Numbers
Customer Service: (800) 227-6666 / (650) 697-3600
Contact Us
Additional Contact Details
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Forgot password?
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Quick Order
MER / MERTK
c-mer proto-oncogene tyrosine kinase
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
| Gene Name: | c-mer proto-oncogene tyrosine kinase |
| Family/Subfamily: | Protein Kinase , Axl |
| Synonyms: | MERTK, Eyk, MER, MER receptor tyrosine kinase, Nyk, Proto-oncogene c-Mer, RP38, STK kinase, C-mer, Receptor tyrosine kinase MerTK, Tyrosine-protein kinase Mer |
| Target Sequences: | NM_006343 NP_006334.2 Q12866 |
Publications (1)
1
MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes. Suresh Babu S, Thandavarayan RA, Joladarashi D, Jeyabal P, Krishnamurthy S, Bhimaraj A, Youker KA, Krishnamurthy P. Scientific reports. 2016 6:36207. (WB; Human)
[Full Text Article]
[PubMed:27827458]
[PMC:PMC5101812]
☰ Filters
Products
Antibodies
(58)
Proteins
(14)
ELISA Kits
(10)
Type
Custom
(3)
Over-Expression Lysate
(2)
Primary
(58)
Recombinant
(12)
Sandwich
(7)
Target
MER / MERTK
(82)
Reactivity
Human
(63)
Mouse
(16)
Rat
(13)
Bovine
(1)
Monkey
(1)
Rabbit
(1)
Application
IHC
(16)
IHC-P
(7)
WB
(47)
Flo
(1)
ELISA
(27)
IF
(3)
IP
(1)
Peptide-ELISA
(7)
Host
rabbit
(46)
mouse
(11)
goat
(1)
Product Group
IHCPlus
(4)
Isotype
IgG
(24)
IgG1
(2)
IgG1,k
(8)
IgG2b
(1)
Clonality
monoclonal mc
(12)
polyclonal pc
(46)
Clone
09
(1)
7E5G1
(1)
A311F9G3
(2)
Format
96-Well Microplate
(3)
96-Well Strip Plate
(7)
APC
(1)
APC Conjugated
(3)
Azide-free
(1)
Biotin Conjugated
(4)
Cy3 Conjugated
(1)
Cy7 Conjugated
(1)
FITC Conjugated
(4)
HRP Conjugated
(4)
PE Conjugated
(3)
Preservative Free
(1)
Unconjugated
(38)
Epitope
aa587-858
(8)
C-Terminus
(6)
N-Terminus
(6)
aa840-999
(2)
10-90 aa, N-terminal
(1)
Extracellular Domain
(1)
aa132-148
(1)
aa200-250
(1)
aa21-120
(1)
aa212-368
(1)
aa30-79
(1)
aa716-765
(1)
aa746-757
(1)
aa946-980
(1)
aa990-999
(1)
p749/681
(1)
pTyr749/681
(1)
pTyr749/Tyr681
(1)
Publications
No
(82)
Sample Type
Cell Culture Supernatants
(5)
Cell Lysates
(5)
Plasma
(2)
Serum
(5)
Tissue Homogenates
(5)
Tag
6His, C-terminus
(1)
DDK (Flag)-His, C-terminus
(1)
DDK,C-terminus
(1)
Fc, C-terminus
(1)
Fc-His, C-terminus
(1)
GST, N-terminus
(1)
His
(1)
His,C-terminus
(1)
His,N-terminus + GST
(1)
His-GST
(1)
Myc-DDK (Flag)
(3)
Species
Human
(11)
Mouse
(2)
Source
293T Cells
(1)
Baculovirus
(1)
E. coli
(1)
HEK 293 Cells
(6)
Human Cells
(1)
Insect Cells
(1)
Mammalian Cells
(1)
Sf9 Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(7)
MER / MERTK Goat anti-Human Polyclonal (aa990-999) Antibody
Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
MER / MERTK Rabbit anti-Human Polyclonal Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
MER / MERTK Rabbit anti-Human Polyclonal (aa716-765) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MER / MERTK Rabbit anti-Human Polyclonal (pTyr749/Tyr681) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MER / MERTK Mouse anti-Human Monoclonal (aa212-368) (7E5G1) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$403
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
Sandwich
96-Well Microplate
Human
0.164 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Serum, Tissue Homogenates
1 Plate/$624
MER / MERTK Rabbit anti-Human Polyclonal (aa746-757) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$1,103
Sandwich
96-Well Strip Plate
Human
312 - 20000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Serum, Tissue Homogenates
1 Plate/$632
MER / MERTK Rabbit anti-Human Monoclonal Antibody
Human
IF, IP, WB
Unconjugated
20 µl/$480; 100 µl/$751
MER / MERTK Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
MER / MERTK Rabbit anti-Mouse Polyclonal (aa946-980) Antibody
Mouse, Rat
Peptide-ELISA, WB
Unconjugated
400 µl/$393
MER / MERTK Mouse anti-Human Monoclonal (Extracellular Domain) (A311F9G3) Antibody
Human
WB
Unconjugated
0.1 ml/$482
MER / MERTK Rabbit anti-Human Polyclonal (aa587-858) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$375
MER / MERTK Rabbit anti-Human Polyclonal (aa840-999) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$375
HEK 293 Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
79.3 kDa
100 µg/$502
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates
1 Plate/$699
MER / MERTK Rabbit anti-Human Polyclonal (aa840-999) Antibody
Human
ELISA, IHC-P, WB
Unconjugated
50 µl/$375
MER / MERTK Rabbit anti-Human Polyclonal (pTyr749/681) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
MER / MERTK Rabbit anti-Human Polyclonal (p749/681) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
MER / MERTK Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$282; 200 µl/$350
MER / MERTK Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
MER / MERTK Mouse anti-Human Monoclonal (aa21-120) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
Viewing 1-25
of 82
product results
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.
