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Antibodies to melanoma antigens, such as clones PNL2 and KBA.62, are useful for the identification of melanoma in immunohistochemistry. PNL2 detects a fixative-resistant melanocyte antigent and allows for staining after decalcification or melanin bleaching. It is used to label neoplastic cells in primary melanomas. KBA.62 also detects a melanoma-associated antigen, and reacts strongly with both benign and malignant melanocytic proliferations and is useful for diagnosing primary and metastatic melanoma, including desmoplastic melanoma (PMIDs 12748255, 18495211, 15675962; DOI: 10.1136/jcp.48.9.826).
Target Name: | Melanoma |
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