MEIS2

Meis homeobox 2

Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3/Meis2B is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3/Meis2B and isoform 4/Meis2D can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5/Meis2E cannot activate DRD1 transcription.

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Products

Proteins (14)

Type

Over-Expression Lysate (10)

Recombinant (4)

Target

MEIS2 (14)

Publications

No (14)

Tag

GST (1)

Myc-DDK (Flag) (13)

Species

Human (9)

Source

293T Cells (5)

HEK 293 Cells (8)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human MEIS2 Protein (Recombinant GST) (Full Length) - LS-G29307

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.65 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MEIS2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65933

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.6 kDa

Price:

20 µg/$1,107

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Human MEIS2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65934

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.9 kDa

Price:

20 µg/$1,107

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Human MEIS2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65935

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.4 kDa

Price:

20 µg/$1,107

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Human MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76589

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.6 kDa

Price:

20 µg/$215

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Human MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76591

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.6 kDa

Price:

20 µg/$150

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Human MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76592

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.9 kDa

Price:

20 µg/$150

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Human MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76586

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.4 kDa

Price:

20 µg/$150

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Human MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76588

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.9 kDa

Price:

20 µg/$150

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MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118006

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

41.4 kDa

Price:

100 µg/$494

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MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105632

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.6 kDa

Price:

100 µg/$710

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MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105633

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.9 kDa

Price:

100 µg/$494

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MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105634

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.9 kDa

Price:

100 µg/$494

Select

MEIS2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G105635

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.6 kDa

Price:

100 µg/$494

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