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MEGF1 / FAT2
FAT atypical cadherin 2
MEGF1 / FAT2 is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development.
| Gene Name: | FAT atypical cadherin 2 |
| Family/Subfamily: | Cadherin , not assigned-Cadherin |
| Synonyms: | FAT2, Cadherin family member 8, HFAT2, FAT tumor suppressor homolog 2, MEGF1, KIAA0811, Protocadherin FAT2, Protocadherin Fat 2, CDHF8, CDHR9 |
| Target Sequences: | NM_001447 NP_001438.1 Q9NYQ8 |
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