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Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Gene Name: | mediator complex subunit 18 |
Synonyms: | MED18, Mediator complex subunit 18, p28b |
Target Sequences: | NM_017638 NP_060108.2 Q9BUE0 |
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