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Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
Gene Name: | mediator complex subunit 15 |
Synonyms: | MED15, CAG7A, CTG repeat protein 7a, CTG7A, Mediator complex subunit 15, TIG1, PCQAP, ARC105, TIG-1, TNRC7, TPA inducible gene-1, TPA inducible protein, TPA-inducible gene 1 protein |
Target Sequences: | NM_015889 NP_056973.2 Q96RN5 |
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