MECP2

methyl CpG binding protein 2 (Rett syndrome)

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

MECP2 (7)

Publications

No (7)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (6)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human MECP2 Protein (Recombinant 6His, C-terminus) (Met1-Ser486) - LS-G39877

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.5kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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MECP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116268

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.3 kDa

Price:

100 µg/$494

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Human MECP2 Protein (Recombinant) (Met1-Lys177) - LS-G133639

Source:

E. coli

Tag:

None

Molecular Weight:

23.4kDa

Price:

10 µg/$304; 50 µg/$587; 200 µg/$1,133; 100 µg/$940; 1 mg/$2,340; 500 µg/$1,848; 5 mg/$4,103; 2 mg/$2,532

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Human MECP2 Protein (Recombinant 6His, C-terminus) (Met1-Ser486) - LS-G140283

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.5 kDa

Price:

10 µg/$317; 50 µg/$524

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Human MECP2 Protein (Recombinant GST, N-terminus) (aa81-170) - LS-G59212

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MECP2 Protein (Recombinant GST) (Full Length) - LS-G29303

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MECP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85102

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.3 kDa

Price:

20 µg/$150

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