MDM4 / MDMX

Mdm4 p53 binding protein homolog (mouse)

MDM4 / MDMX is a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

MDM4 / MDMX (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human MDM4 / MDMX Protein (Recombinant GST) (Full Length) - LS-G29299

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.3 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MDM4 / MDMX Protein (Recombinant GST, N-terminus) (aa381-490) - LS-G59209

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MDM4 / MDMX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80103

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.7 kDa

Price:

20 µg/$150

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MDM4 / MDMX Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99739

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.7 kDa

Price:

100 µg/$494

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Human MDM4 / MDMX Protein (Recombinant His) (aa261-490) - LS-G141148

Source:

E. coli

Sequence Length:

229 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

25.3 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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