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MDM4 / MDMX
Mdm4 p53 binding protein homolog (mouse)
MDM4 / MDMX is a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
| Gene Name: | Mdm4 p53 binding protein homolog (mouse) |
| Synonyms: | MDM4, Mdm2-like p53-binding protein, MDMX, HDMX, MRP1, p53-binding protein Mdm4, Protein Mdm4, Double minute 4 protein, MDM4-related protein 1, Protein Mdmx |
| Target Sequences: | NM_002393 NP_002384.2 O15151 |
Publications (2)
1
Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival. Liu T, Zhang H, Xiong J, Yi S, Gu L, Zhou M. Molecular cancer. 2015 14:65. (WB; Human)
[Full Text Article]
[PubMed:25888903]
[PMC:PMC4379586]
Related Antibodies: LS-B4097.
2
FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2. Liu T, Xiong J, Yi S, Zhang H, Zhou S, Gu L, Zhou M. Oncogene. 2017 36:1678-1686. (WB; Human)
[Full Text Article]
[PubMed:27617579]
Related Antibodies: LS-B4097.
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MDM4 / MDMX Mouse anti-Human Monoclonal (aa 2-185) (2D10F4) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MDM4 / MDMX Mouse anti-Human Monoclonal (OTI2C1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MDM4 / MDMX Mouse anti-Human Monoclonal (3B9) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MDM4 / MDMX Rabbit anti-Human Polyclonal (aa2-113) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$332
MDM4 / MDMX Mouse anti-Human Monoclonal (4G5) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MDM4 / MDMX Mouse anti-Human Monoclonal (4G3) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MDM4 / MDMX Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
0.1 mg/$379
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
MDM4 / MDMX Rabbit anti-Human Polyclonal (aa130-179) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
MDM4 / MDMX Mouse anti-Human Monoclonal (OTI4B10) Antibody
Human
IF, WB
Unconjugated
100 µl/$434
MDM4 / MDMX Mouse anti-Human Monoclonal (2D10F4) Antibody
Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$541
MDM4 / MDMX Rabbit anti-Human Polyclonal (aa125-175) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
MDM4 / MDMX Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$332; 100 µg/$404; 200 µg/$505
MDM4 / MDMX Mouse anti-Human Monoclonal (OTI1D11) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MDM4 / MDMX Mouse anti-Human Monoclonal (Carrier-free) (OTI1D11) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MDM4 / MDMX Mouse anti-Human Monoclonal (OTI3H2) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MDM4 / MDMX Mouse anti-Human Monoclonal (Carrier-free) (OTI3H2) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MDM4 / MDMX Mouse anti-Human Monoclonal (OTI2D11) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MDM4 / MDMX Mouse anti-Human Monoclonal (Carrier-free) (OTI2D11) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MDM4 / MDMX Mouse anti-Human Monoclonal (OTI4B5) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MDM4 / MDMX Mouse anti-Human Monoclonal (Carrier-free) (OTI4B5) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MDM4 / MDMX Mouse anti-Human Monoclonal (OTI2B8) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MDM4 / MDMX Mouse anti-Human Monoclonal (OTI3A6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MDM4 / MDMX Mouse anti-Human Monoclonal (OTI2E11) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MDM4 / MDMX Mouse anti-Human Monoclonal (Carrier-free) (3B9) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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