MDM2

MDM2 oncogene, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.

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Products

ELISA Kits (8)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Custom (4)

Sandwich (2)

Target

MDM2 (8)

Reactivity

Human (5)

Mouse (4)

Dog (1)

Format

96-Well Microplate (3)

96-Well Strip Plate (5)

Publications

No (8)

Sample Type

Adherent Cell Cultures (2)

Cell Lysates (2)

Tissue Homogenates (2)

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Mouse MDM2 (Sandwich ELISA) ELISA Kit - LS-F8527

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$748

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Mouse/Human MDM2 (Cell-Based ELISA) ELISA Kit - LS-F2136

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$534

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Mouse/Human Phospho-MDM2 (Ser166) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1187

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Human MDM2 (Sandwich ELISA) ELISA Kit - LS-F9205

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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Human MDM2 (Custom ELISA) ELISA Kit - LS-F50505

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$823

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Dog MDM2 (Custom) ELISA Kit - LS-F65746

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Price:

1 Plate/$783

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Human MDM2 (Custom) ELISA Kit - LS-F66350

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Price:

1 Plate/$669

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Mouse MDM2 (Custom) ELISA Kit - LS-F65613

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$669

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