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MDK / Midkine
midkine (neurite growth-promoting factor 2)
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development.
| Gene Name: | midkine (neurite growth-promoting factor 2) |
| Synonyms: | MDK, ARAP, MK, MK1, NEGF2, Midkine, Retinoic acid inducible factor |
| Target Sequences: | NM_002391 NP_002382.1 P21741 |
Publications (3)
1
High-level soluble expression, purification and characterization of active human midkine from Escherichia coli. Yan WK, Goette M, Hofmann G, Zaror I, Sim J. Protein expression and purification. 2010 70:270-6. (WB)
[PubMed:19883768]
2
DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma. Meng X, Duan C, Pang H, Chen Q, Han B, Zha C, Dinislam M, Wu P, Li Z, Zhao S, Wang R, Lin L, Jiang C, Cai J. EBioMedicine. 2019 March;41:185-199. [Full Text Article]
[PubMed:30773478]
[PMC:PMC6442002]
3
Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Lim JS, Ibaseta A, Fischer MM, Cancilla B, O'Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu YW, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J. Nature. 2017 May;545:360-364. [Full Text Article]
[PubMed:28489825]
[PMC:PMC5776014]
☰ Filters
Products
Proteins
(23)
Type
Over-Expression Lysate
(8)
Recombinant
(15)
Target
MDK / Midkine
(23)
Publications
No
(23)
Tag
6His, N-terminus
(1)
GST
(2)
His
(1)
His, N-Terminal
(1)
His-S
(2)
His-T7
(1)
Myc-DDK (Flag)
(11)
Species
Human
(16)
Mouse
(2)
Rat
(1)
Source
293T Cells
(4)
E. coli
(11)
HEK 293 Cells
(7)
Wheat Germ Extract
(1)
Purification
Purified
(5)
Low Endotoxin Level
Low endotoxin level
(4)
Biologically Active
Biologically active
(4)
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~14 kDa
20 µg/$301; 100 µg/$490; 1 mg/$1,891
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
13.3 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
13.4 kDa
5 µg/$268; 20 µg/$349
E. coli
None
Biologically active
13.4 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
E. coli
His-S
19.0 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His, N-Terminal
18.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
E. coli
His-S
18.8 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
His-T7
17.1 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
GST
40.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Wheat Germ Extract
GST
41.47 kDa
2 µg/$439
HEK 293 Cells
Myc-DDK (Flag)
15.4 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
15.4 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
15.4 kDa
20 µg/$1,107
HEK 293 Cells
Myc-DDK (Flag)
15.4 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
15.4 kDa
100 µg/$494
HEK 293 Cells
Myc-DDK (Flag)
15.4 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
15.4 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
15.4 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
15.4 kDa
20 µg/$150
293T Cells
Myc-DDK (Flag)
15.4 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
15.4 kDa
100 µg/$494
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
100 µg/$361; 500 µg/$739; 20 µg/$261
E. coli
6His, N-terminus
13 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Viewing 1-23
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product results
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