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Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene Name: | malate dehydrogenase 1, NAD (soluble) |
Synonyms: | MDH1, Cytosolic malate dehydrogenase, Diiodophenylpyruvate reductase, MOR2, MDH-s, MDHA, MGC:1375, Soluble malate dehydrogenase |
Target Sequences: | NM_005917 NP_005908.1 P40925 |
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