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Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol.
Gene Name: | biphenyl hydrolase-like (serine hydrolase) |
Synonyms: | BPHL, MCNAA, Valacyclovir hydrolase, Valacyclovirase, VACVASE, BPH-RP |
Target Sequences: | NM_004332 NP_004323.2 Q86WA6 |
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