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MCL1 / MCL 1

myeloid cell leukemia sequence 1 (BCL2-related)

Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

Gene Name: myeloid cell leukemia sequence 1 (BCL2-related)
Synonyms: MCL1, BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Bcl2-L-3, MCL1S, MCL1L, Myeloid cell leukemia ES, MCL 1, MCL1-ES, TM, EAT, Mcl-1
Target Sequences: NM_021960 NP_068779.1 Q07820

Publications (5)

1
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Molecular and cellular biology. 2007 27:4328-39. [PubMed:17371841] [PMC:PMC1900055]
2
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Vogler M, Butterworth M, Majid A, Walewska RJ, Sun XM, Dyer MJ, Cohen GM. Blood. 2009 113:4403-13. (IP) [PubMed:19008458]
3
The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation. Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J. Journal of immunology (Baltimore, Md. : 1950). 2010 185:6670-8. [PubMed:21048108]
4
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. The Journal of biological chemistry. 2011 286:5921-33. [PubMed:21159778] [PMC:PMC3037705]
5
A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. Baumgartner CK, Yagita H, Malherbe LP. Journal of immunology (Baltimore, Md. : 1950). 2012 189:2309-17. [PubMed:22844120] [PMC:PMC3424363]
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ELISA Kits (10)
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MCL1 / MCL 1 (10)
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MCL1 / MCL 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
MCL1 / MCL 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 U/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MCL1 / MCL 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MCL1 / MCL 1 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
MCL1 / MCL 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MCL1 / MCL 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$748
MCL1 / MCL 1 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
MCL1 / MCL 1 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
MCL1 / MCL 1 ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
MCL1 / MCL 1 ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$610
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).