Products
Research Areas
COVID-19
Resources
Login
Quick Order
Cart Cart lightblue
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us

Location


Corporate Headquarters

Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

Telephone Numbers



Customer Service: (800) 227-6666 / (650) 697-3600


Contact Us



Additional Contact Details

Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

MCL1 / MCL 1

myeloid cell leukemia sequence 1 (BCL2-related)

Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

Gene Name: myeloid cell leukemia sequence 1 (BCL2-related)
Synonyms: MCL1, BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Bcl2-L-3, MCL1S, MCL1L, Myeloid cell leukemia ES, MCL 1, MCL1-ES, TM, EAT, Mcl-1
Target Sequences: NM_021960 NP_068779.1 Q07820

Publications (5)

1
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Molecular and cellular biology. 2007 27:4328-39. [PubMed:17371841] [PMC:PMC1900055]
2
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Vogler M, Butterworth M, Majid A, Walewska RJ, Sun XM, Dyer MJ, Cohen GM. Blood. 2009 113:4403-13. (IP) [PubMed:19008458]
3
The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation. Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J. Journal of immunology (Baltimore, Md. : 1950). 2010 185:6670-8. [PubMed:21048108]
4
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. The Journal of biological chemistry. 2011 286:5921-33. [PubMed:21159778] [PMC:PMC3037705]
5
A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. Baumgartner CK, Yagita H, Malherbe LP. Journal of immunology (Baltimore, Md. : 1950). 2012 189:2309-17. [PubMed:22844120] [PMC:PMC3424363]
more

☰ Filters
Antibodies (126)
ELISA Kits (10)
Proteins (8)
Cell-Based (1)
Custom (4)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (2)
Primary (126)
Recombinant (5)
Sandwich (5)
MCL1 / MCL 1 (144)
Human (118)
Mouse (59)
Rat (28)
Bovine (1)
Dog (5)
Guinea pig (2)
Hamster (1)
Horse (2)
Monkey (5)
Pig (4)
Rabbit (4)
IHC (67)
IHC-Fr (2)
IHC-P (24)
WB (113)
Flo (14)
ELISA (41)
ICC (4)
IF (36)
IP (4)
Peptide-ELISA (6)
rabbit (96)
mouse (28)
goat (2)
Product Group
IHCPlus (7)
IgG (55)
IgG1 (14)
IgG2a (11)
IgG2b (2)
monoclonal mc (29)
polyclonal pc (97)
06 (1)
10C5 (2)
2.00E+11 (1)
2E11 (1)
8C6D4B1 (2)
GF1 (1)
MCL.C9 (1)
OTI10D10 (2)
OTI10F6 (2)
OTI2D6 (2)
OTI3A12 (2)
OTI3B4 (2)
OTI4B7 (2)
OTI9C9 (2)
OTI9D7 (2)
96-Well Microplate (2)
96-Well Strip Plate (8)
APC (2)
APC Conjugated (5)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 594 Conjugated (1)
Azide-free (2)
Biotin Conjugated (8)
Carrier-free (10)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (8)
HRP Conjugated (7)
PE Conjugated (5)
PerCP Conjugated (1)
Preservative Free (3)
RPE Conjugated (1)
Unconjugated (84)
aa2-307 (8)
aa6-328 (8)
aa191-226 (7)
aa217-245 (7)
pSer159 (3)
C-Terminus (2)
aa121-139 (2)
100-180 aa (1)
60-140 aa, Internal (1)
Internal (1)
Ser121 (1)
Ser155 (1)
Ser64 (1)
aa1-350 (1)
aa106-155 (1)
aa125-174 (1)
aa303-325 (1)
aa339-350 (1)
aa75-125 (1)
aa91-140 (1)
p159 (1)
No (144)
Adherent Cell Cultures (1)
Cell Lysates (1)
Plasma (4)
Serum (4)
Tissue Homogenates (3)
6His, N-terminus (1)
His (1)
His, N-Terminal (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (3)
Human (5)
Mouse (2)
293T Cells (1)
E. coli (4)
HEK 293 Cells (3)
Purified (1)
MCL1 / MCL 1 Antibody - Anti-MCL1 / MCL 1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
MCL1 / MCL 1 Mouse anti-Human Monoclonal (2E11) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
MCL1 / MCL 1 Mouse anti-Human Monoclonal (8C6D4B1) Antibody
Human
ELISA, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µl/$460
MCL1 / MCL 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$730
MCL1 / MCL 1 Protein - Recombinant Myeloid Cell Leukemia Sequence 1, Bcl2 Related By SDS-PAGE
Select
E. coli
His, N-Terminal
36.6 kDa
10 µg/$284; 50 µg/$460; 100 µg/$735; 200 µg/$917; 1 mg/$2,037; 500 µg/$1,571; 5 mg/$3,207; 2 mg/$2,225
MCL1 / MCL 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.56 - 100 U/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MCL1 / MCL 1 Protein
Select
E. coli
His
50 µg/$411; 250 µg/$985; 10 µg/$276
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
MCL1 / MCL 1 Mouse anti-Human Monoclonal (8C6D4B1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
MCL1 / MCL 1 Antibody - MCL1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa217-245) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
MCL1 / MCL 1 Antibody - IHC of paraffin-embedded breast tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
Select
MCL1 / MCL 1 Mouse anti-Human Monoclonal (OTI10F6) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MCL1 / MCL 1 Antibody - IHC of paraffin-embedded Kidney tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
Select
MCL1 / MCL 1 Mouse anti-Human Monoclonal (OTI10D10) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:25.
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa121-139) Antibody
Human
IHC, IHC-P
Unconjugated
250 µl/$495
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa191-226) (Biotin) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa191-226) (FITC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa191-226) (APC) Antibody
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
MCL1 / MCL 1 Antibody - Anti-MCL1 antibody IHC of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal Antibody
Rabbit, Dog, Guinea pig, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$485
MCL1 / MCL 1 Antibody - Immunocytochemistry of Mcl-1 in Raji cells with Mcl-1 antibody at 10 ug/ml.
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, WB
Unconjugated
0.1 mg/$460
Select
MCL1 / MCL 1 Mouse anti-Human Monoclonal (MCL.C9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$352
MCL1 / MCL 1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
MCL1 / MCL 1 Mouse anti-Human Monoclonal (10C5) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
MCL1 / MCL 1 Antibody - Immunohistochemistry of paraffin-embedded human pancreas using MCL1 antibodyat dilution of 1:100 (40x lens).
Select
MCL1 / MCL 1 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated
20 µl/$299; 100 µl/$431
MCL1 / MCL 1 Antibody - Western blot of recombinant MCL1 / MCL 1.
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa6-328) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
Select
MCL1 / MCL 1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µl/$872
MCL1 / MCL 1 Protein
Select
E. coli
His-T7
38.4 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
MCL1 / MCL 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MCL1 / MCL 1 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MCL1 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
MCL1 / MCL 1 Rabbit anti-Human Polyclonal (aa91-140) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Viewing 1-25 of 144 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).