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MCF2 / DBL

MCF.2 cell line derived transforming sequence

Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.

Gene Name: MCF.2 cell line derived transforming sequence
Synonyms: MCF2, DBL, Oncogene MCF2 (oncogene DBL), Proto-oncogene MCF-2, ARHGEF21, Proto-oncogene DBL
Target Sequences: NM_005369 NP_005360.3 P10911

Publications (1)

1
Highly variable cancer subpopulations that exhibit enhanced transcriptome variability and metastatic fitness. Nguyen A, Yoshida M, Goodarzi H, Tavazoie SF. Nature communications. 2016 7:11246. (WB; Human) [Full Text Article] [PubMed:27138336] [PMC:PMC4857405] Related Antibodies: LS-C164083.

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MCF2 / DBL (4)
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MCF2 / DBL Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
116.6 kDa
20 µg/$215
MCF2 / DBL Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
100.9 kDa
20 µg/$215
MCF2 / DBL Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
116.6 kDa
100 µg/$710
MCF2 / DBL Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
100.9 kDa
100 µg/$710
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).