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Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation.
Gene Name: | mutated in colorectal cancers |
Synonyms: | MCC, MCC1, Protein MCC, Mutated in colorectal cancers |
Target Sequences: | nm_002387 NP_002378.1 P23508 |
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