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MCAM / CD146

melanoma cell adhesion molecule

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene Name: melanoma cell adhesion molecule
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: MCAM, CD146, CD146 antigen, Gicerin, Melanoma adhesion molecule, MUC18, p1h12
Target Sequences: NM_006500 NP_006491.2 P43121

Publications (3)

1
Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. The Journal of investigative dermatology. 2015 135:1849-1862. (WB; Human) [Full Text Article] [PubMed:25756799] [PMC:PMC4466041] Related Antibodies: LS-B4050.
2
TDP-43 Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS) and Frontal Cortex in sALS/FTLD-TDP. Isidro Ferrer , Pol Andrés-Benito , Margarita Carmona , Abdelilah Assialioui, Mónica Povedano. Journal of neuropathology and experimental neurology. 2021 Feb;80:229-239. [Full Text Article] [PubMed:33421065] [PMC:PMC7899266] Related Antibodies: LS-B10746.
3
Hepatic stellate cells support hematopoiesis and are liver-resident mesenchymal stem cells. Claus Kordes, Iris Sawitza, Silke Götze, Dieter Häussinger. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2013 March;31:290-304. [Full Text Article] [PubMed:23485574] Related Antibodies: LS-C35841.

☰ Filters
Products
ELISA Kits (19)
Custom (1)
Sandwich (16)
Sandwich CLIA (2)
MCAM / CD146 (19)
Human (8)
Mouse (5)
Rat (1)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (15)
No (19)
Cell Culture Supernatants (3)
Cell Supernatant (1)
Plasma (12)
Serum (13)
Tissue Homogenates (3)
Tissue Supernatants (1)
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Tissue Supernatants
1 Plate/$669
MCAM / CD146 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$798
MCAM / CD146 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$715
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MCAM / CD146 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
MCAM / CD146 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.205 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$559
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$968
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Guinea pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MCAM / CD146 ELISA Kit
Select
Sandwich
Human
62.5 - 4000 pg/ml
Cell Culture Supernatants, Serum
1 Plate/$699
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$598
MCAM / CD146 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MCAM / CD146 ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
0.055 - 40 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$871
Viewing 1-19 of 19 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).