MC1R

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

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Products

Antibodies (29)

Type

Primary (29)

Target

MC1R (29)

Reactivity

Human (26)

Mouse (9)

Rat (3)

Chimpanzee (3)

Monkey (2)

Orangutan (3)

Application

IHC (8)

IHC-P (4)

WB (23)

ELISA (9)

IF (5)

Peptide-ELISA (2)

Host

rabbit (27)

mouse (1)

rabbit-new zealand white (1)

Product Group

GPCR Database Antibodies (1)

IHCPlus (2)

Isotype

IgG (17)

IgM (1)

Clonality

monoclonal mc (1)

polyclonal pc (28)

Format

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (23)

Epitope

C-Terminus (5)

240-320 aa, C-terminal (1)

3rd Cytoplasmic Domain (1)

Cytoplasmic Domain (1)

Internal (1)

Val312 (1)

aa2-50 (1)

aa205-232 (1)

aa253-317 (1)

aa263-312 (1)

Publications

No (29)

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IHC-plus™ MC1R Antibody (Cytoplasmic Domain) LS-A1040

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(4.0) Rating

Antibody:

MC1R Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$440

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IHC-plus™ MC1R Antibody (aa205-232) LS-B10498

(4.0) Rating

Antibody:

MC1R Mouse anti-Human Monoclonal (aa205-232) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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MC1R Antibody LS-C8968

Antibody:

MC1R Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$513; 100 µg/$860

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MC1R Antibody LS-C332324

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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MC1R Antibody LS-C402431

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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MC1R Antibody LS-C405709

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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MC1R Antibody (Internal) LS-C153483

Antibody:

MC1R Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human, Monkey

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$440; 100 µg/$480

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MC1R Antibody LS-C670652

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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MC1R Antibody (240-320 aa, C-terminal) LS-C384454

Antibody:

MC1R Rabbit anti-Human Polyclonal (240-320 aa, C-terminal) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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MC1R Antibody LS-C825100

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

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MC1R Antibody LS-C801365

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MC1R Antibody (aa253-317) LS-C185954

Antibody:

MC1R Rabbit anti-Human Polyclonal (aa253-317) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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MC1R Antibody LS-C417071

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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MC1R Antibody (3rd Cytoplasmic Domain) LS-C16499

Antibody:

MC1R Rabbit anti-Mouse Polyclonal (3rd Cytoplasmic Domain) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$884

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MC1R Antibody (Val312) LS-C177159

Antibody:

MC1R Rabbit anti-Human Polyclonal (Val312) Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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MC1R Antibody (aa2-50) LS-C829693

Antibody:

MC1R Rabbit-New Zealand White anti-Human Polyclonal (aa2-50) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$393

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MC1R Antibody (aa263-312) LS-C200234

Antibody:

MC1R Rabbit anti-Human Polyclonal (aa263-312) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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MC1R Antibody (C-Terminus) LS-C8969

Antibody:

MC1R Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse

Applications:

ELISA

Format:

Unconjugated

Price:

100 µl/$801

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MC1R Antibody (C-Terminus) LS-C169728

Antibody:

MC1R Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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MC1R Antibody (C-Terminus, Biotin) LS-C470732

Antibody:

MC1R Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human, Chimpanzee, Orangutan

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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MC1R Antibody (C-Terminus, FITC) LS-C470733

Antibody:

MC1R Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human, Chimpanzee, Orangutan

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin
• FITC

• Unconjugated
• Biotin
• FITC

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MC1R Antibody LS-C662033

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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MC1R Antibody LS-C781995

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$575

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MC1R Antibody LS-C748560

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

MC1R Antibody LS-C748215

Antibody:

MC1R Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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