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MBTPS1 / S1P

membrane-bound transcription factor peptidase, site 1

Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Gene Name: membrane-bound transcription factor peptidase, site 1
Family/Subfamily: Exopeptidase , Serine S8
Synonyms: MBTPS1, Endopeptidase S1P, PCSK8, KIAA0091, Site-1 protease, Subtilisin/kexin isozyme-1, S1P, SKI-1, SKI1, Subtilisin/kexin-isozyme 1
Target Sequences: NM_003791 NP_003782.1 Q14703

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Products
Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
MBTPS1 / S1P (5)
No (5)
6His-SUMO, N-terminus (1)
GST, N-terminus (2)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
MBTPS1 / S1P Protein - 12.5% SDS-PAGE of human MBTPS1 stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
87.7 kDa
2 µg/$439
MBTPS1 / S1P Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
117.75 kDa
100 µg/$710
MBTPS1 / S1P Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
117.75 kDa
20 µg/$215
MBTPS1 / S1P Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MBTPS1 / S1P Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Viewing 1-5 of 5 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).