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MBP / Myelin Basic Protein
myelin basic protein
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
| Gene Name: | myelin basic protein |
| Synonyms: | MBP, Myelin A1 protein, Myelin basic protein |
| Target Sequences: | NM_002385 NP_002376.1 P02686 |
Publications (5)
1
Cranial nerve involvement in patients with MOG antibody-associated disease. Cobo-Calvo A, Ayrignac X, Kerschen P, Horellou P, Cotton F, Labauge P, Vukusic S, Deiva K, Serguera C, Marignier R. Neurology(R) neuroimmunology & neuroinflammation. 2019 February;6:e543. [Full Text Article]
[PubMed:30800725]
[PMC:PMC6384017]
Related Antibodies: LS-B2231.
2
Staurosporine, an inhibitor of hormonally up-regulated neu-associated kinase. Zambrano JN, Williams CJ, Williams CB, Hedgepeth L, Burger P, Dilday T, Eblen ST, Armeson K, Hill EG, Yeh ES. Oncotarget. 2018 November;9:35962-35973. [Full Text Article]
[PubMed:30542510]
[PMC:PMC6267597]
3
pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. David Kremer, Joel Gruchot, Vivien Weyers, Lisa Oldemeier, Peter Göttle, Luke Healy, Jeong Ho Jang, Yu Kang T Xu, Christina Volsko, Ranjan Dutta, Bruce D Trapp, Hervé Perron, Hans-Peter Hartung, Patrick Küry. Proceedings of the National Academy of Sciences of the United States of America. 2019 Jul;116:15216-15225. [Full Text Article]
[PubMed:31213545]
[PMC:PMC6660731]
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MBP / Myelin Basic Protein
(189)
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(116)
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(2)
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(2)
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(1)
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(1)
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(1)
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(1)
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MBP / Myelin Basic Protein Mouse anti-Human Monoclonal (aa130-136) Antibody
Rabbit, Mouse, Goat, Sheep, Rat, Primate, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$535
MBP / Myelin Basic Protein Mouse anti-Rat Monoclonal (7D2) Antibody
Rat
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
Neuroscience
MBP / Myelin Basic Protein Rat anti-Bovine Monoclonal (aa82-87) (12) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Guinea pig, Rat, Pig, Mammal, Human
ELISA, IHC, IHC-P, RIA, WB
Unconjugated
125 µl/$460
MBP / Myelin Basic Protein Rabbit anti-Human Polyclonal (aa49-62) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
0.1 mg/$460
Neuroscience
MBP / Myelin Basic Protein Chicken anti-Human Polyclonal Antibody
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$555
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$764
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
Sandwich
96-Well Microplate
Rat
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
E. coli
His, N-Terminal
26.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
293F Cells
His, N-Terminal
46kDa
10 µg/$307; 50 µg/$602; 200 µg/$1,156; 100 µg/$962; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,201; 2 mg/$2,562
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
MBP / Myelin Basic Protein Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$564
MBP / Myelin Basic Protein Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
MBP / Myelin Basic Protein Rabbit anti-Guinea pig Polyclonal (aa69-86) Antibody
Guinea pig, Rat, Human
IHC
Unconjugated
50 µl/$884
MBP / Myelin Basic Protein Mouse anti-Human Monoclonal (aa215-221) (QD-9) Antibody
Human
Unconjugated
100 µg/$352
MBP / Myelin Basic Protein Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$361
MBP / Myelin Basic Protein Rabbit anti-Human Polyclonal (aa135-190) Antibody
Mouse, Rat, Pig, Human
WB
Unconjugated
100 µl/$299; 200 µl/$336; 500 µl/$462; 1 ml/$525; 2 ml/$677; 5 ml/$1,136
E. coli
His-GST
38 kDa
10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646
Neuroscience
MBP / Myelin Basic Protein Mouse anti-Human Monoclonal (13B511) Antibody
Human
ELISA, Flo, ICC, IHC-P, WB
Unconjugated
50 µl/$485
MBP / Myelin Basic Protein Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$413
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