MBD1

methyl-CpG binding domain protein 1

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.

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Products

Antibodies (41)

Proteins (10)

ELISA Kits (1)

Type

Over-Expression Lysate (8)

Primary (41)

Recombinant (2)

Sandwich (1)

Target

MBD1 (52)

Reactivity

Human (42)

Mouse (8)

Rat (4)

Bat (9)

Bovine (9)

Chimpanzee (9)

Dog (9)

Gibbon (9)

Guinea pig (9)

Horse (9)

Monkey (13)

Orangutan (9)

Pig (9)

Rabbit (9)

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Application

IHC (13)

IHC-P (10)

WB (36)

Flo (1)

ELISA (3)

IF (3)

Peptide-ELISA (1)

Host

rabbit (30)

mouse (11)

Product Group

IHCPlus (2)

Isotype

IgG (22)

IgG1 (8)

IgG1,k (1)

IgG2b,k (1)

Clonality

monoclonal mc (10)

polyclonal pc (31)

Clone

100B272.1 (1)

100B272.1. (1)

2C7 (1)

OTI1A1 (1)

OTI2D7 (2)

OTI2H5 (2)

Format

96-Well Microplate (1)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (6)

Carrier-free (2)

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HRP Conjugated (6)

PE Conjugated (1)

Unconjugated (20)

Epitope

C-Terminus (17)

aa222-556 (5)

aa391-405 (1)

aa98-113 (1)

Publications

No (52)

Sample Type

Plasma (1)

Serum (1)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (8)

Species

Human (6)

Source

293T Cells (4)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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MBD1 Antibody (C-Terminus) LS-C31263

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

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MBD1 Antibody (C-Terminus) LS-B12681

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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MBD1 Antibody (C-Terminus, HRP) LS-C428384

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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MBD1 Antibody (C-Terminus, Biotin) LS-C428383

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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MBD1 Antibody (C-Terminus, FITC) LS-C428385

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Rabbit, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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MBD1 Antibody (clone 2C7) LS-C133910

Antibody:

MBD1 Mouse anti-Human Monoclonal (2C7) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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MBD1 Antibody (C-Terminus) LS-B1545

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

MBD1 Antibody (C-Terminus, HRP) LS-C427242

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

MBD1 Antibody (C-Terminus, Biotin) LS-C427240

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

MBD1 Antibody (C-Terminus, FITC) LS-C427241

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

MBD1 Antibody LS-C672572

Antibody:

MBD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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Human MBD1 (Sandwich ELISA) ELISA Kit - LS-F21285

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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MBD1 Antibody LS-C806942

Antibody:

MBD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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MBD1 Antibody (C-Terminus) LS-C178931

Antibody:

MBD1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

Select

MBD1 Antibody (aa222-556, clone OTI2H5) LS-C796093

Antibody:

MBD1 Mouse anti-Human Monoclonal (aa222-556) (OTI2H5) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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MBD1 Antibody (aa222-556, clone OTI2H5, Carrier-free) LS-C792936

Antibody:

MBD1 Mouse anti-Human Monoclonal (aa222-556) (Carrier-free) (OTI2H5) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

MBD1 Antibody LS-C308904

Antibody:

MBD1 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$705

Select

MBD1 Antibody LS-C72245

Antibody:

MBD1 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$649

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MBD1 Antibody (aa391-405, clone 100B272.1, Azide-free) LS-C368276

Antibody:

MBD1 Mouse anti-Human Monoclonal (aa391-405) (Azide-free) (100B272.1) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated, Azide-free

Price:

0.1 mg/$386

Select

MBD1 Antibody (clone 100B272.1.) LS-C563

Antibody:

MBD1 Mouse anti-Human Monoclonal (100B272.1.) Antibody

Reactivity:

Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

0.1 mg/$386

Select

MBD1 Antibody (aa222-556, clone OTI1A1) LS-C796091

Antibody:

MBD1 Mouse anti-Human Monoclonal (aa222-556) (OTI1A1) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

MBD1 Antibody (aa222-556, clone OTI2D7) LS-C796094

Antibody:

MBD1 Mouse anti-Human Monoclonal (aa222-556) (OTI2D7) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

MBD1 Antibody (aa222-556, clone OTI2D7, Carrier-free) LS-C792937

Antibody:

MBD1 Mouse anti-Human Monoclonal (aa222-556) (Carrier-free) (OTI2D7) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

MBD1 Antibody LS-C310955

Antibody:

MBD1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

Select

MBD1 Antibody (FITC) LS-C783073

Antibody:

MBD1 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

Flo

Format:

FITC Conjugated

Price:

100 µg/$414

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