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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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MASP1 / MASP
mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MASP1 / MASP is a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.
| Gene Name: | mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) |
| Family/Subfamily: | Protease , Serine S1 |
| Synonyms: | MASP1, 3MC1, Complement factor MASP-3, CRARF, MAP1, MAp44, MASP3, MASP, MASP-3, PRSS5, Serine protease 5, MASP-1, RaRF, CRARF1 |
| Target Sequences: | NM_001879 NP_001870.3 P48740 |
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