MARK2

MAP/microtubule affinity-regulating kinase 2

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.

☰ Filters

Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

MARK2 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

Human MARK2 Protein (Recombinant His, N-Terminal) - LS-G144525

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

82.9 kDa

Price:

50 µg/$419

Select

Human MARK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78734

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

81 kDa

Price:

20 µg/$150

Select

Human MARK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78735

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.9 kDa

Price:

20 µg/$215

Select

Human MARK2 Protein (Recombinant GST) (Full Length) - LS-G28342

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

110.7 kDa

Price:

2 µg/$439

Select

Human MARK2 Protein (Recombinant GST, N-terminus) (aa401-500) - LS-G58449

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human MARK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66928

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

81 kDa

Price:

20 µg/$1,107

Select

MARK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112444

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

82.9 kDa

Price:

100 µg/$710

Select

MARK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116293

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

81 kDa

Price:

100 µg/$494

Viewing 1-8 of 8 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.