MARK2

MAP/microtubule affinity-regulating kinase 2

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.

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Products

Antibodies (41)

Proteins (8)

Type

Over-Expression Lysate (4)

Primary (41)

Recombinant (4)

Target

MARK2 (49)

Reactivity

Human (41)

Mouse (24)

Rat (17)

Bovine (2)

Dog (2)

Hamster (1)

Monkey (1)

Application

IHC (17)

IHC-P (8)

WB (31)

ELISA (16)

ICC (2)

IF (12)

IP (3)

Peptide-ELISA (6)

Host

rabbit (39)

mouse (1)

goat (1)

Product Group

IHCPlus (3)

Isotype

IgG (31)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (40)

Clone

3B12 (1)

Format

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (25)

Epitope

aa600-630 (7)

C-Terminus (4)

10-90 aa, N-terminal (1)

540-620 aa (1)

Ab-596 (1)

Internal (1)

N-Terminus (1)

aa1-755 (1)

aa10-59 (1)

aa13-62 (1)

aa300-350 (1)

aa350-400 (1)

aa500-510 (1)

aa562-611 (1)

pThr595 (1)

pThr596 (1)

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Publications

No (49)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ MARK2 Antibody (aa10-59) LS-B7503

(4.0) Rating

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa10-59) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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IHC-plus™ MARK2 Antibody (aa562-611) LS-B7004

(4.0) Rating

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa562-611) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$460

Select

MARK2 Antibody (Internal) LS-C368416

Antibody:

MARK2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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MARK2 Antibody (N-Terminus) LS-C356174

Antibody:

MARK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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MARK2 Antibody (phospho-Thr595) LS-C18889

Antibody:

MARK2 Rabbit anti-Human Polyclonal (pThr595) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$567

Select

MARK2 Antibody (aa600-630) LS-C99815

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa600-630) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

IHC-plus™ MARK2 Antibody (aa13-62) LS-B14681

(4.0) Rating

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa13-62) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

MARK2 Antibody LS-C752833

Antibody:

MARK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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MARK2 Antibody (Ab-596) LS-C822890

Antibody:

MARK2 Rabbit anti-Human Polyclonal (Ab-596) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

MARK2 Antibody LS-C804557

Antibody:

MARK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

MARK2 Antibody (10-90 aa, N-terminal) LS-C384431

Antibody:

MARK2 Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

MARK2 Antibody LS-C823022

Antibody:

MARK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

MARK2 Antibody (clone 3B12) LS-C197132

Antibody:

MARK2 Mouse anti-Human Monoclonal (3B12) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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MARK2 Antibody LS-C831224

Antibody:

MARK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

MARK2 Antibody LS-C830003

Antibody:

MARK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

MARK2 Antibody LS-C671109

Antibody:

MARK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

MARK2 Antibody (540-620 aa) LS-C381771

Antibody:

MARK2 Rabbit anti-Human Polyclonal (540-620 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

MARK2 Antibody (phospho-Thr596) LS-C291174

Antibody:

MARK2 Rabbit anti-Human Polyclonal (pThr596) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MARK2 Antibody (aa600-630) LS-C330533

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa600-630) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

MARK2 Antibody (aa600-630, Biotin) LS-C279253

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa600-630) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

MARK2 Antibody (aa600-630, FITC) LS-C279254

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa600-630) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

MARK2 Antibody (aa600-630, APC) LS-C279251

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa600-630) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

MARK2 Antibody (aa600-630, Azide-free, HRP) LS-C279255

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa600-630) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

MARK2 Antibody (aa600-630, PE) LS-C279256

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa600-630) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

MARK2 Antibody (aa350-400) LS-C289835

Antibody:

MARK2 Rabbit anti-Human Polyclonal (aa350-400) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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