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E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.
Gene Name: | membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase |
Synonyms: | MARCH8, C-MIR, RING finger protein 178, RNF178, MARCH-VIII, MIR |
Target Sequences: | NP_659458.2 Q5T0T0 |
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