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Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
Gene Name: | membrane-associated ring finger (C3HC4) 5 |
Synonyms: | MARCH5, MARCH-V, RING finger protein 153, RNF153, Mitochondrial ubiquitin ligase, MITOL |
Target Sequences: | NM_017824 NP_060294.1 Q9NX47 |
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