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MAPT / Tau

microtubule-associated protein tau

Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments (PHF) and straight filaments, mainly composed of hyperphosphorylated forms of TAU.

Gene Name: microtubule-associated protein tau
Synonyms: MAPT, FTDP-17, MSTD, Neurofibrillary tangle protein, PHF-tau, MTBT2, PPND, DDPAC, MAPTL, MTBT1, Paired helical filament-tau, TAU
Target Sequences: NM_016835 P10636

Publications (3)

1
Hyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease. Puri R, Suzuki T, Yamakawa K, Ganesh S. The Journal of biological chemistry. 2009 284:22657-63. (IHC, WB) [PubMed:19542233] [PMC:PMC2755673]
2
Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells. Fu ZQ, Shao QL, Shen JL, Zhang YJ, Zhao XX, Yao L. Journal of neuroimmunology. 2010 221:15-24. (ICC, WB) [PubMed:20163877]
3
Serum levels of tau protein increase according to the severity of the injury in DAI rat model. Keisuke Tomita, Taka-Aki Nakada, Taku Oshima, Rui Kawaguchi, Shigeto Oda. F1000Research. 2020 December;9:29. [Full Text Article] [PubMed:33299544] [PMC:PMC7707115]

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MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$715
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$587
MAPT / Tau ELISA Kit
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Sandwich
96-Well Microplate
Pig
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
MAPT / Tau ELISA Kit
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Sandwich
96-Well Microplate
Human
7.81 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MAPT / Tau ELISA Kit
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Sandwich
96-Well Microplate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MAPT / Tau ELISA Kit
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Sandwich
96-Well Microplate
Mouse
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$759
MAPT / Tau ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
MAPT / Tau ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$750
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$776
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates
1 Plate/$812
MAPT / Tau ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
MAPT / Tau ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
MAPT / Tau ELISA Kit
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Sandwich
96-Well Microplate
Human
102.4 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$760
MAPT / Tau ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
MAPT / Tau ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
MAPT / Tau ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
MAPT / Tau ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Rat
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MAPT / Tau ELISA Kit
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Sandwich
96-Well Strip Plate
Human
7.8 - 500 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).