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MAPK14 / p38

mitogen-activated protein kinase 14

MAP kinase p38 alpha, a MAPK type protein kinase, is an environmental stress- and inflammatory cytokine-induced kinase that is associated with the regulation of gene expression, cell proliferation and cell death. p38alpha is phosphorylated by MEK3/MAP2K3 or MKK6/MAP2K6. Activated p38alpha either remains in the cytosol, where it phosphorylates cytosolic proteins including MNK1/2, PLA2 and PRAK, or translocates to the nucleus, where it phosphorylates several substrates, including ATF2, CHOP/GADD153, MAPKAPK-2 and -3, MEF2-A and -C, MSK, Myc binding partner Max and Sap-1a. At least four protein isoforms, resulting from alternatively spliced transcript variants of this gene, have been identified - 297, 307 and two isoforms of 360 amino acids with differing internal segments.

Gene Name: mitogen-activated protein kinase 14
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK14, CSAID-binding protein, CSBP2, CSPB1, CSBP1, Csaids binding protein, CSBP, EXIP, MAP kinase 14, MAP kinase p38 alpha, MAX-interacting protein 2, MAPK 14, p38 alpha, PRKM15, PRKM14, RK, SAPK2A, MAP kinase MXI2, Mxi2, p38ALPHA, p38, p38 MAP kinase, p38alpha Exip
Target Sequences: NM_001315 NP_001306.1 Q16539

Publications (3)

1
Preconditioning by inhaled nitric oxide prevents hyperoxic and ischemia/reperfusion injury in rat lungs. Waldow T, Witt W, Ulmer A, Janke A, Alexiou K, Matschke K. Pulmonary pharmacology & therapeutics. 2008 21:418-29. (WB) [PubMed:18453045]
2
Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs. Kim HW, Ju JH, Shin JI, Seung BJ, Sur JH. Journal of veterinary science. 2017 December;18:479-485. (Rat) [Full Text Article] [PubMed:28927257] [PMC:PMC5746441] Related Antibodies: LS-C212.
3
Critical role for integrin-4 in the attenuation of murine acute lung injury by simvastatin. Chen W, Sammani S, Mitra S, Ma SF, Garcia JG, Jacobson JR. American journal of physiology. Lung cellular and molecular physiology. 2012 303:L279-85. [PubMed:22683568] [PMC:PMC3423831] Related Antibodies: LS-B1634.

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Products
Proteins (16)
Over-Expression Lysate (6)
Recombinant (10)
MAPK14 / p38 (16)
No (16)
GST (2)
GST, N-terminus (2)
His (1)
His, N-Terminal (1)
His-T7 (1)
Myc-DDK (Flag) (9)
Human (13)
293T Cells (3)
E. coli (3)
HEK 293 Cells (6)
Wheat Germ Extract (4)
Purified (4)
MAPK14 / p38 Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
MAPK14 / p38 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MAPK14 / p38 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MAPK14 / p38 Protein - Purified recombinant protein MAPK14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
41.3 kDa
20 µg/$1,107
MAPK14 / p38 Protein - Purified recombinant protein MAPK14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
41.1 kDa
20 µg/$1,107
MAPK14 / p38 Protein - Purified recombinant protein MAPK14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35.3 kDa
20 µg/$1,107
MAPK14 / p38 Protein - 12.5% SDS-PAGE of human MAPK14 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.34 kDa
10 µg/$479; 25 µg/$670
MAPK14 / p38 Protein - 12.5% SDS-PAGE of human MAPK14 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.23 kDa
10 µg/$479; 25 µg/$670
MAPK14 / p38 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
41.3 kDa
20 µg/$150
MAPK14 / p38 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
33.9 kDa
20 µg/$150
MAPK14 / p38 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
41.1 kDa
20 µg/$150
MAPK14 / p38 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.1 kDa
100 µg/$494
MAPK14 / p38 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
33.9 kDa
100 µg/$494
MAPK14 / p38 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
41.3 kDa
100 µg/$494
MAPK14 / p38 Protein
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E. coli
His, N-Terminal
44 kDa
10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315; 500 µg/$949
MAPK14 / p38 Protein - Recombinant Mitogen Activated Protein Kinase 14 By SDS-PAGE
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E. coli
His-T7
33.2 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).