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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States

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Customer Service: (800) 227-6666 / (650) 697-3600


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MAPK14 / p38

mitogen-activated protein kinase 14

MAP kinase p38 alpha, a MAPK type protein kinase, is an environmental stress- and inflammatory cytokine-induced kinase that is associated with the regulation of gene expression, cell proliferation and cell death. p38alpha is phosphorylated by MEK3/MAP2K3 or MKK6/MAP2K6. Activated p38alpha either remains in the cytosol, where it phosphorylates cytosolic proteins including MNK1/2, PLA2 and PRAK, or translocates to the nucleus, where it phosphorylates several substrates, including ATF2, CHOP/GADD153, MAPKAPK-2 and -3, MEF2-A and -C, MSK, Myc binding partner Max and Sap-1a. At least four protein isoforms, resulting from alternatively spliced transcript variants of this gene, have been identified - 297, 307 and two isoforms of 360 amino acids with differing internal segments.

Gene Name: mitogen-activated protein kinase 14
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK14, CSAID-binding protein, CSBP2, CSPB1, CSBP1, Csaids binding protein, CSBP, EXIP, MAP kinase 14, MAP kinase p38 alpha, MAX-interacting protein 2, MAPK 14, p38 alpha, PRKM15, PRKM14, RK, SAPK2A, MAP kinase MXI2, Mxi2, p38ALPHA, p38, p38 MAP kinase, p38alpha Exip
Target Sequences: NM_001315 NP_001306.1 Q16539

Publications (3)

1
Preconditioning by inhaled nitric oxide prevents hyperoxic and ischemia/reperfusion injury in rat lungs. Waldow T, Witt W, Ulmer A, Janke A, Alexiou K, Matschke K. Pulmonary pharmacology & therapeutics. 2008 21:418-29. (WB) [PubMed:18453045]
2
Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs. Kim HW, Ju JH, Shin JI, Seung BJ, Sur JH. Journal of veterinary science. 2017 December;18:479-485. (Rat) [Full Text Article] [PubMed:28927257] [PMC:PMC5746441] Related Antibodies: LS-C212.
3
Critical role for integrin-4 in the attenuation of murine acute lung injury by simvastatin. Chen W, Sammani S, Mitra S, Ma SF, Garcia JG, Jacobson JR. American journal of physiology. Lung cellular and molecular physiology. 2012 303:L279-85. [PubMed:22683568] [PMC:PMC3423831] Related Antibodies: LS-B1634.

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ELISA Kits (24)
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MAPK14 / p38 (24)
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MAPK14 / p38 ELISA Kit
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Sandwich Phosphorylation
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$661
MAPK14 / p38 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
MAPK14 / p38 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
MAPK14 / p38 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
MAPK14 / p38 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
MAPK14 / p38 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$750
MAPK14 / p38 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
MAPK14 / p38 ELISA Kit
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Custom
96-Well Strip Plate
Dog
Colorimetric - 450nm (TMB)
1 Plate/$783
MAPK14 / p38 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$669
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Microplate
Human
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Microplate
Rat
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MAPK14 / p38 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
12.5 - 800 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
2.5 - 160 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
12.5 - 800 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MAPK14 / p38 ELISA Kit
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Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).