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MAPK14 / p38
mitogen-activated protein kinase 14
MAP kinase p38 alpha, a MAPK type protein kinase, is an environmental stress- and inflammatory cytokine-induced kinase that is associated with the regulation of gene expression, cell proliferation and cell death. p38alpha is phosphorylated by MEK3/MAP2K3 or MKK6/MAP2K6. Activated p38alpha either remains in the cytosol, where it phosphorylates cytosolic proteins including MNK1/2, PLA2 and PRAK, or translocates to the nucleus, where it phosphorylates several substrates, including ATF2, CHOP/GADD153, MAPKAPK-2 and -3, MEF2-A and -C, MSK, Myc binding partner Max and Sap-1a. At least four protein isoforms, resulting from alternatively spliced transcript variants of this gene, have been identified - 297, 307 and two isoforms of 360 amino acids with differing internal segments.
| Gene Name: | mitogen-activated protein kinase 14 |
| Family/Subfamily: | Protein Kinase , MAPK |
| Synonyms: | MAPK14, CSAID-binding protein, CSBP2, CSPB1, CSBP1, Csaids binding protein, CSBP, EXIP, MAP kinase 14, MAP kinase p38 alpha, MAX-interacting protein 2, MAPK 14, p38 alpha, PRKM15, PRKM14, RK, SAPK2A, MAP kinase MXI2, Mxi2, p38ALPHA, p38, p38 MAP kinase, p38alpha Exip |
| Target Sequences: | NM_001315 NP_001306.1 Q16539 |
Publications (3)
1
Preconditioning by inhaled nitric oxide prevents hyperoxic and ischemia/reperfusion injury in rat lungs. Waldow T, Witt W, Ulmer A, Janke A, Alexiou K, Matschke K. Pulmonary pharmacology & therapeutics. 2008 21:418-29. (WB)
[PubMed:18453045]
2
Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs. Kim HW, Ju JH, Shin JI, Seung BJ, Sur JH. Journal of veterinary science. 2017 December;18:479-485. (Rat)
[Full Text Article]
[PubMed:28927257]
[PMC:PMC5746441]
Related Antibodies: LS-C212.
3
Critical role for integrin-4 in the attenuation of murine acute lung injury by simvastatin. Chen W, Sammani S, Mitra S, Ma SF, Garcia JG, Jacobson JR. American journal of physiology. Lung cellular and molecular physiology. 2012 303:L279-85.
[PubMed:22683568]
[PMC:PMC3423831]
Related Antibodies: LS-B1634.
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ELISA Kits
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MAPK14 / p38
(222)
Reactivity
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MAPK14 / p38 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MAPK14 / p38 Rabbit anti-Rat Polyclonal (pThr180/Tyr182) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Human
IHC, WB
Unconjugated
100 µl/$469
MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr182) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MAPK14 / p38 Mouse anti-Human Monoclonal (aa299-360) (8G4D11) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
MAPK14 / p38 Mouse anti-Human Monoclonal (N-Terminus) Antibody
Mouse, Human
ELISA, IP, WB
Unconjugated
100 µg/$794
MAPK14 / p38 Rabbit anti-Human Polyclonal Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey
IHC, IP, WB
Unconjugated
25 µl/$290; 100 µl/$372
MAPK14 / p38 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
MAPK14 / p38 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
MAPK14 / p38 Rabbit anti-Human Polyclonal (Tyr323) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
MAPK14 / p38 Rabbit anti-Human Polyclonal (Internal) Antibody
Zebrafish, Rat, Mouse, Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
MAPK14 / p38 Rabbit anti-Human Polyclonal (260-340 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr182) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
MAPK14 / p38 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 100 µl/$409
MAPK14 / p38 Rabbit anti-Human Polyclonal (Internal) Antibody
Zebrafish, Rat, Mouse, Dog, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
MAPK14 / p38 Rabbit anti-Human Polyclonal (Thr180/Tyr182) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
MAPK14 / p38 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr182) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$489
MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr182) Antibody
Zebrafish, Rat, Mouse, Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$341
MAPK14 / p38 Rabbit anti-Human Polyclonal (260-340 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MAPK14 / p38 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Rat, Mouse, Dog, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr323) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MAPK14 / p38 Rabbit anti-Human Polyclonal (p322) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
MAPK14 / p38 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
MAPK14 / p38 Rabbit anti-Human Polyclonal (aa157-192) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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