MAP4K1 / HPK1

mitogen-activated protein kinase kinase kinase kinase 1

HPK1, a KHS protein kinase, is an upstream activator of the stress-activated protein kinase (SAPK) signaling pathway. The protein has a structure similar to other GCK (Group I) kinases and contains four consensus SH3 binding motifs, which have been shown to interact with the SH3 motifs of the MAP kinase kinase kinases MLK3 and MEKK1 and several adapter proteins that couple to tyrosine kinases, including BASH, Blnk, Clnk, Crk, CrkL and Grb2. Additionally, HPK1 has been shown to be phosphorylated and activated by the tyrosine kinase c-Abl in response to genotoxic agents. At least two mRNA transcripts have been reported.

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Products

Antibodies (36)

Proteins (4)

ELISA Kits (3)

Type

Over-Expression Lysate (2)

Primary (36)

Recombinant (2)

Sandwich (3)

Target

MAP4K1 / HPK1 (43)

Reactivity

Human (38)

Mouse (15)

Rat (5)

Bat (3)

Bovine (3)

Chimpanzee (6)

Dog (6)

Gibbon (6)

Guinea pig (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (6)

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Application

IHC (9)

IHC-P (3)

WB (29)

DB (6)

ELISA (18)

IF (1)

IP (2)

Peptide-ELISA (4)

Host

rabbit (35)

goat (1)

Product Group

IHCPlus (2)

Isotype

Ig (3)

IgG (26)

Clonality

polyclonal pc (36)

Format

96-Well Microplate (1)

96-Well Strip Plate (2)

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (20)

Epitope

aa321-350 (7)

pSer171 (6)

aa218-267 (4)

aa61-110 (4)

340-420 aa, Internal (1)

Leu397 (1)

Ser421 (1)

aa1-50 (1)

aa2-14 (1)

aa348-397 (1)

aa371-420 (1)

aa550-600 (1)

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Publications

No (43)

Sample Type

Cell Lysates (1)

Plasma (2)

Serum (2)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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IHC-plus™ MAP4K1 / HPK1 Antibody (aa2-14) LS-B6447

(4.0) Rating

Antibody:

MAP4K1 / HPK1 Goat anti-Human Polyclonal (aa2-14) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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MAP4K1 / HPK1 Antibody LS-C809293

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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Human MAP4K1 / HPK1 (Sandwich ELISA) ELISA Kit - LS-F66714

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human MAP4K1 / HPK1 (Sandwich ELISA) ELISA Kit - LS-F74388

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$595

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Mouse MAP4K1 / HPK1 (Sandwich ELISA) ELISA Kit - LS-F65595

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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MAP4K1 / HPK1 Antibody (Leu397) LS-C176829

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (Leu397) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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MAP4K1 / HPK1 Antibody (aa321-350) LS-C327915

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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MAP4K1 / HPK1 Antibody (aa321-350, Biotin) LS-C279595

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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MAP4K1 / HPK1 Antibody (aa321-350, FITC) LS-C279596

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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MAP4K1 / HPK1 Antibody (aa321-350, APC) LS-C279594

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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MAP4K1 / HPK1 Antibody (aa321-350, Azide-free, HRP) LS-C279597

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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MAP4K1 / HPK1 Antibody (aa321-350, PE) LS-C279599

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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MAP4K1 / HPK1 Antibody LS-C757802

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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MAP4K1 / HPK1 Antibody (phospho-Ser171, PE) LS-C279592

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (pSer171) (PE) Antibody

Reactivity:

Human

Applications:

DB, ELISA

Format:

PE Conjugated

Price:

200 µl/$952

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MAP4K1 / HPK1 Antibody (aa218-267) LS-C80801

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa218-267) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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MAP4K1 / HPK1 Antibody (aa218-267, FITC) LS-C448367

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa218-267) (FITC) Antibody

Reactivity:

Mouse, Dog, Rat, Pig, Horse, Bat, Gibbon, Chimpanzee, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• FITC

• Unconjugated
• FITC

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MAP4K1 / HPK1 Antibody (aa550-600) LS-C288688

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa550-600) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

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IHC-plus™ MAP4K1 / HPK1 Antibody (aa1-50) LS-B15060

(4.0) Rating

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$485

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MAP4K1 / HPK1 Antibody (aa321-350) LS-C99779

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa321-350) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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MAP4K1 / HPK1 Antibody (340-420 aa, Internal) LS-C384011

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (340-420 aa, Internal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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MAP4K1 / HPK1 Antibody (aa61-110) LS-C201503

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa61-110) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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MAP4K1 / HPK1 Antibody (aa61-110, FITC) LS-C448370

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal (aa61-110) (FITC) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Pig, Orangutan, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• FITC

• Unconjugated
• FITC

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Human MAP4K1 / HPK1 Protein (Recombinant GST) (Full Length) - LS-G32550

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

118.58 kDa

Price:

2 µg/$439

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MAP4K1 / HPK1 Antibody LS-C666632

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

Select

MAP4K1 / HPK1 Antibody LS-C757501

Antibody:

MAP4K1 / HPK1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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