MAP3K7 / TAK1

mitogen-activated protein kinase kinase kinase 7

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

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Proteins (9)

Type

Over-Expression Lysate (6)

Recombinant (3)

Target

MAP3K7 / TAK1 (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (7)

Species

Human (6)

Source

293T Cells (3)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human MAP3K7 / TAK1 Protein (Recombinant GST, N-terminus) (aa471-579) - LS-G60280

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAP3K7 / TAK1 Protein (Recombinant GST) (Full Length) - LS-G30618

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

89.43 kDa

Price:

10 µg/$479; 25 µg/$670

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MAP3K7 / TAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117496

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64 kDa

Price:

100 µg/$494

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Human MAP3K7 / TAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79901

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67 kDa

Price:

20 µg/$215

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Human MAP3K7 / TAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79903

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.5 kDa

Price:

20 µg/$215

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Human MAP3K7 / TAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79902

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64 kDa

Price:

20 µg/$150

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Human MAP3K7 / TAK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67464

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64 kDa

Price:

20 µg/$1,107

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MAP3K7 / TAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106645

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

67 kDa

Price:

100 µg/$710

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MAP3K7 / TAK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106646

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

56.5 kDa

Price:

100 µg/$710

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