MAP3K3 / MEKK3

mitogen-activated protein kinase kinase kinase 3

MAP3K3 / MEKK3 is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

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Products

Antibodies (28)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (28)

Recombinant (2)

Target

MAP3K3 / MEKK3 (32)

Reactivity

Human (20)

Mouse (15)

Rat (3)

Monkey (1)

Application

IHC (7)

IHC-P (3)

WB (27)

ELISA (11)

ICC (1)

IF (3)

Peptide-ELISA (2)

Host

rabbit (26)

mouse (2)

Isotype

IgG (22)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (27)

Clone

1H3 (1)

Format

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (18)

Epitope

aa228-257 (7)

Internal (2)

aa11-25 (2)

70-150 aa, Internal (1)

aa101-150 (1)

aa125-175 (1)

Publications

No (32)

Tag

GST (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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MAP3K3 / MEKK3 Antibody (Internal) LS-C354035

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 50 µl/$271; 100 µl/$299; 200 µl/$351

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MAP3K3 / MEKK3 Antibody (70-150 aa, Internal) LS-C384483

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal (70-150 aa, Internal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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MAP3K3 / MEKK3 Antibody (aa11-25) LS-C313061

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Mouse Polyclonal (aa11-25) Antibody

Reactivity:

Mouse, Rat

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$470

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MAP3K3 / MEKK3 Antibody LS-C800531

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$282; 200 µl/$350

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MAP3K3 / MEKK3 Antibody LS-C827821

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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MAP3K3 / MEKK3 Antibody LS-C827823

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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MAP3K3 / MEKK3 Antibody (Internal) LS-C155322

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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MAP3K3 / MEKK3 Antibody (aa228-257) LS-C329805

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Mouse Polyclonal (aa228-257) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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MAP3K3 / MEKK3 Antibody (aa228-257, Biotin) LS-C262569

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Mouse Polyclonal (aa228-257) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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MAP3K3 / MEKK3 Antibody (aa228-257, FITC) LS-C262572

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Mouse Polyclonal (aa228-257) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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MAP3K3 / MEKK3 Antibody (aa228-257, APC) LS-C262570

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Mouse Polyclonal (aa228-257) (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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MAP3K3 / MEKK3 Antibody (aa228-257, Azide-free, HRP) LS-C262573

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Mouse Polyclonal (aa228-257) (Azide-free) (HRP) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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MAP3K3 / MEKK3 Antibody (aa228-257, PE) LS-C262574

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Mouse Polyclonal (aa228-257) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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MAP3K3 / MEKK3 Antibody (clone 1H3) LS-C197671

Antibody:

MAP3K3 / MEKK3 Mouse anti-Human Monoclonal (1H3) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$335

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MAP3K3 / MEKK3 Antibody LS-C826890

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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MAP3K3 / MEKK3 Antibody LS-C833666

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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MAP3K3 / MEKK3 Antibody (aa101-150) LS-C119225

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal (aa101-150) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MAP3K3 / MEKK3 Antibody (aa228-257) LS-C164454

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Mouse Polyclonal (aa228-257) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

MAP3K3 / MEKK3 Antibody LS-C311381

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

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MAP3K3 / MEKK3 Antibody (APC) LS-C514791

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal (APC) Antibody

Reactivity:

Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$937

Select

MAP3K3 / MEKK3 Antibody (PE) LS-C651251

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal (PE) Antibody

Reactivity:

Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$937

• Unconjugated
• APC
• PE

• Unconjugated
• APC
• PE

Select

MAP3K3 / MEKK3 Antibody (aa125-175) LS-C289831

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal (aa125-175) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

MAP3K3 / MEKK3 Antibody LS-C416107

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$305; 100 µl/$357

Select

MAP3K3 / MEKK3 Antibody (aa11-25) LS-C313060

Antibody:

MAP3K3 / MEKK3 Rabbit anti-Human Polyclonal (aa11-25) Antibody

Reactivity:

Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$470

Select

MAP3K3 / MEKK3 Antibody LS-C309207

Antibody:

MAP3K3 / MEKK3 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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