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MAP3K12 is a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.
Gene Name: | mitogen-activated protein kinase kinase kinase 12 |
Family/Subfamily: | Protein Kinase , MLK(MAP3K) |
Synonyms: | MAP3K12, Dual leucine zipper kinase DLK, Dlk, Dual leucine zipper kinase, Leucine zipper protein kinase, Leucine-zipper protein kinase, MAPK-upstream kinase, MEKK12, Mixed lineage kinase, Protein kinase MUK, MUK, ZPK, ZPKP1 |
Target Sequences: | NM_006301 NP_006292.3 Q12852 |
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