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Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
Gene Name: | mitogen-activated protein kinase kinase kinase 11 |
Family/Subfamily: | Protein Kinase , MLK(MAP3K) |
Synonyms: | MAP3K11, Mixed lineage kinase 3, MLK3, Protein-tyrosine kinase PTK1, PTK1, SPRK, MLK-3, MEKK11 |
Target Sequences: | NM_002419 NP_002410.1 Q16584 |
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