MAP2K7 / MEK7

mitogen-activated protein kinase kinase 7

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

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Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

MAP2K7 / MEK7 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human MAP2K7 / MEK7 Protein (Recombinant His-T7) (aa113-388) - LS-G15339

Source:

E. coli

Tag:

His-T7

Molecular Weight:

35.2 kDa

Price:

10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029

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Mouse MAP2K7 / MEK7 Protein (Recombinant His-T7) (aa181-429) - LS-G15341

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.0 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human MAP2K7 / MEK7 Protein (Recombinant GST, N-terminus) (aa1-99) - LS-G59756

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAP2K7 / MEK7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80041

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.3 kDa

Price:

20 µg/$215

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Human MAP2K7 / MEK7 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67517

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.3 kDa

Price:

20 µg/$1,107

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Human MAP2K7 / MEK7 Protein (Recombinant GST) (Full Length) - LS-G29927

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

74.6 kDa

Price:

2 µg/$439

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MAP2K7 / MEK7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G106759

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

47.3 kDa

Price:

100 µg/$710

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