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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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MAP2K3 / MEK3 / MKK3
mitogen-activated protein kinase kinase 3
MAP2K3 / MEK3 / MKK3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
| Gene Name: | mitogen-activated protein kinase kinase 3 |
| Family/Subfamily: | Protein Kinase , MAP2K |
| Synonyms: | MAP2K3, MAPKK 3, MAPKK3, PRKMK3, SAPK kinase 2, SAPKK-2, SAPKK2, SKK2, MAP kinase kinase 3, MEK 3, MEK3, MKK3, MAPK/ERK kinase 3 |
| Target Sequences: | NM_002756 NP_002747.2 P46734 |
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Antibodies
(135)
Proteins
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ELISA Kits
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Type
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Cell-Based Phosphorylation
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Primary
(135)
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(7)
Target
MAP2K3 / MEK3 / MKK3
(147)
Reactivity
Human
(138)
Mouse
(74)
Rat
(65)
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(6)
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(7)
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(56)
Gibbon
(6)
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(4)
Hamster
(2)
Horse
(5)
Monkey
(42)
Pig
(1)
Rabbit
(6)
Zebrafish
(4)
Application
IHC
(65)
IHC-P
(33)
WB
(130)
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(1)
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(24)
ICC
(3)
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(60)
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(6)
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(6)
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rabbit
(72)
mouse
(63)
Product Group
IHCPlus
(2)
Isotype
IgG
(50)
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(7)
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(1)
IgG2a
(22)
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(32)
Clonality
monoclonal mc
(62)
polyclonal pc
(73)
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(1)
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(30)
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(1)
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(6)
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(6)
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(1)
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(106)
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aa320-334
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160-240 aa
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Ser183
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(4)
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(8)
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(1)
E. coli
(3)
HEK 293 Cells
(3)
Wheat Germ Extract
(2)
Purification
Purified
(2)
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (1D10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI1H6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Rabbit anti-Human Polyclonal (pThr222) Antibody
Zebrafish, Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI5F2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI5D7) Antibody
Dog, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI5D3) Antibody
Mouse, Dog, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI5B2) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI5C7) Antibody
Dog, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI5F9) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI6F8) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI6C6) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI4B3) Antibody
Mouse, Dog, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI2A7) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI6B11) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (Carrier-free) (OTI6B11) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (2E12D11) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI1B5) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI6B12) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Rabbit anti-Human Polyclonal (aa173-222) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI3C8) Antibody
Mouse, Dog, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI4G4) Antibody
Mouse, Dog, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Mouse, Human
ICC, IF, IHC-P, IP, WB
Unconjugated, Preservative Free
100 µl/$412
MAP2K3 / MEK3 / MKK3 Mouse anti-Human Monoclonal (OTI5E2) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K3 / MEK3 / MKK3 Rabbit anti-Human Polyclonal (pSer189) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MAP2K3 / MEK3 / MKK3 Rabbit anti-Human Polyclonal (aa1-170) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
Viewing 1-25
of 147
product results
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