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6737 Mowry Ave
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MAP2K1 / MKK1 / MEK1
mitogen-activated protein kinase kinase 1
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.
| Gene Name: | mitogen-activated protein kinase kinase 1 |
| Family/Subfamily: | Protein Kinase , MAP2K |
| Synonyms: | MAP2K1, ERK activator kinase 1, MAPK/ERK kinase 1, MAPKK 1, MKK1, PRKMK1, MEK 1, MAP kinase kinase 1, MAPKK1, MEK1 |
| Target Sequences: | NM_002755 NP_002746.1 Q02750 |
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MAP2K1 / MKK1 / MEK1
(285)
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MAP2K1 / MKK1 / MEK1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Xenopus, Rat, Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µg/$485
MAP2K1 / MKK1 / MEK1 Rabbit anti-Mouse Monoclonal (Preservative Free) (131) Antibody
Mouse
ICC, IF, WB
Unconjugated, Preservative Free
100 µl/$412
MAP2K1 / MKK1 / MEK1 Rabbit anti-Human Polyclonal (Internal) Antibody
Rabbit, Mouse, Bovine, Rat, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$299
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (pSer218/Ser222) Antibody
Mouse, Dog, Human
ELISA, WB
Unconjugated
100 µg/$845
MAP2K1 / MKK1 / MEK1 Mouse anti-Mouse Monoclonal Antibody
Mouse
IP, WB
Unconjugated
100 µg/$801
MAP2K1 / MKK1 / MEK1 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human, Monkey
ELISA, WB
Unconjugated
100 µl/$688
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI3E6) Antibody
Mouse, Dog, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI3B4) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2B2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2A1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI4H8) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2A9) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI4F1) Antibody
Mouse, Dog, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI3H5) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI3H3) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI7B1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI8A6) Antibody
Mouse, Dog, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI1A10) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI4E4) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2F12) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2F1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI7E2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI6C6) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI4B1) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K1 / MKK1 / MEK1 Mouse anti-Human Monoclonal (OTI2H3) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
Viewing 1-25
of 285
product results
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