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Mannose Receptor / CD206

mannose receptor, C type 1

The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.

Gene Name: mannose receptor, C type 1
Synonyms: MRC1, BA541I19.1, CLEC13D, CD206, CD206 antigen, Macrophage mannose receptor 1, Mannose Receptor, Macrophage mannose receptor, MMR, Mannose receptor, C type 1, MRC1L1, CLEC13DL
Target Sequences: NM_002438 NP_002429.1 P22897

Publications (6)

1
Spermatozoa capture HIV-1 through heparan sulfate and efficiently transmit the virus to dendritic cells. Ana Ceballos, Federico Remes Lenicov, Juan Sabatté, Christian Rodríguez Rodrígues, Mercedes Cabrini, Carolina Jancic, Silvina Raiden, Mónica Donaldson, Rodolfo Agustín Pasqualini Jr., Clara Marin-Briggiler, Mónica Vazquez-Levin, Francisco Capani, Sebastiá. The Journal of experimental medicine. 2009 206:2717-33. (Func; Human) [Full Text Article] [PubMed:19858326] [PMC:PMC2806607]
2
CD73 Activity is Dispensable for the Polarization of M2 Macrophages. Eichin D, Laurila JP, Jalkanen S, Salmi M. PloS one. 2015 10:e0134721. (WB; Human) [Full Text Article] [PubMed:26258883] [PMC:PMC4530872] Related Antibodies: LS-C40886.
3
CD163 macrophage and erythrocyte contents in aspirated deep vein thrombus are associated with the time after onset: a pilot study. Eiji Furukoji , Toshihiro Gi , Atsushi Yamashita, Sayaka Moriguchi-Goto, Mio Kojima, Chihiro Sugita, Tatefumi Sakae, Yuichiro Sato, Toshinori Hirai, Yujiro Asada. Thrombosis journal. 2016 November;14:46. [Full Text Article] [PubMed:27895532] [PMC:PMC5120412] Related Antibodies: LS-B5474.
4
N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats. Arina I Ponomarenko, Anna A Tyrtyshnaia, Evgeny A Pislyagin, Inessa V Dyuizen, Ruslan M Sultanov, Igor V Manzhulo. Scientific reports. 2021 January;11:756. [Full Text Article] [PubMed:33436960] [PMC:PMC7804312]
5
Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages. Hao Wu, Yijie Han, Yasmina Rodriguez Sillke, Hongzhang Deng, Sophiya Siddiqui, Christoph Treese, Franziska Schmidt, Marie Friedrich, Jacqueline Keye, Jiajia Wan, Yue Qin, Anja A Kühl, Zhihai Qin, Britta Siegmund, Rainer Glauben. EMBO molecular medicine. 2019 November;11:e10698. [Full Text Article] [PubMed:31602788] [PMC:PMC6835560] Related Antibodies: LS-B5474.
6
Recovery of Renal Function following Kidney-Specific VEGF Therapy in Experimental Renovascular Disease. Jason E Engel, Maxx L Williams, Erika Williams, Camille Azar, Erin B Taylor, Gene L Bidwell, Alejandro R Chade. American journal of nephrology. 2020 November;51:891-902. [Full Text Article] [PubMed:33130676] [PMC:PMC7750286] Related Antibodies: LS-B9805.
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Proteins (5)
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Mannose Receptor / CD206 (5)
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6His, N-terminus (1)
GST, N-terminus (1)
His (1)
His-SUMO (1)
His-T7 (1)
Human (4)
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E. coli (3)
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Mannose Receptor / CD206 Protein
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E. coli
His-SUMO
80.33 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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Yeast
His
66.38 kD
1 mg/$1,607; 100 µg/$469; 20 µg/$349
Mannose Receptor / CD206 Protein - Recombinant Mannose Receptor C Type 1 By SDS-PAGE
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E. coli
His-T7
34.1 kDa
10 µg/$283; 50 µg/$452; 100 µg/$725; 200 µg/$905; 1 mg/$2,020; 500 µg/$1,558; 5 mg/$3,165; 2 mg/$2,209
Mannose Receptor / CD206 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Mannose Receptor / CD206 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
69.9 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).