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MANF / ARMET

mesencephalic astrocyte-derived neurotrophic factor

MANF / ARMET is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

Gene Name: mesencephalic astrocyte-derived neurotrophic factor
Synonyms: MANF, ARP, ARMET, Arginine-rich protein, Protein ARMET
Target Sequences: NM_006010 NP_006001.4 P55145

Publications (4)

1
Piperine ameliorates SCA17 neuropathology by reducing ER stress. Guo J, Cui Y, Liu Q, Yang Y, Li Y, Weng L, Tang B, Jin P, Li XJ, Yang S, Li S. Molecular neurodegeneration. 2018 January;13:4. (Human) [Full Text Article] [PubMed:29378605] [PMC:PMC5789626] Related Antibodies: LS-B2688.
2
Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice. Galli E, Rossi J, Neumann T, Andressoo JO, Drinda S, Lindholm P. Science advances. 2019 October;9:14318. [Full Text Article] [PubMed:31586115] [PMC:PMC6778185] Related Antibodies: LS-B2688.
3
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function. Danilova T, Galli E, Pakarinen E, Palm E, Lindholm P, Saarma M, Lindahl M. Frontiers in endocrinology. 2019 November;10: [Full Text Article] [PubMed:31781038] [PMC:PMC6851024] Related Antibodies: LS-B2688.
4
MANF Is Neuroprotective in Early Stages of EAE, and Elevated in Spinal White Matter by Treatment With Dexamethasone. Jinhan Nam, Tapani K Koppinen, Merja H Voutilainen. Frontiers in cellular neuroscience. 2021 Jul;15:640084. [Full Text Article] [PubMed:34305531] [PMC:PMC8292680] Related Antibodies: LS-B2688.
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ELISA Kits (19)
Custom (3)
Development Kit (1)
Sandwich (14)
Sandwich CLIA (1)
MANF / ARMET (19)
Human (8)
Mouse (2)
Rat (3)
Chicken (1)
Guinea pig (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Product Group
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12 x 8-Well Microstrips (1)
96-Well Microplate (1)
96-Well Strip Plate (15)
Antibody Pair and Standard (1)
No (19)
Cell Culture Supernatants (5)
Cell Lysates (4)
EDTA Plasma (1)
Heparin Plasma (1)
Plasma (10)
Serum (11)
Tissue Homogenates (6)
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$854
MANF / ARMET ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$730
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MANF / ARMET ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,120; 1000 Wells/$1,642
MANF / ARMET ELISA Kit
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Sandwich
96-Well Strip Plate
Guinea pig
0.781 - 50 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.781 - 50 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
0.625 - 40 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$783
MANF / ARMET ELISA Kit
Select
Sandwich
Human
93.6 - 6000 pg/ml
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$901
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$851
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MANF / ARMET ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
MANF / ARMET ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
MANF / ARMET ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
MANF / ARMET ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
Viewing 1-19 of 19 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).