MALIN / NHLRC1

NHL repeat containing E3 ubiquitin protein ligase 1

E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway.

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Products

Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

MALIN / NHLRC1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human MALIN / NHLRC1 Protein (Recombinant GST, N-terminus) (aa137-246) - LS-G63945

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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MALIN / NHLRC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103604

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.1 kDa

Price:

100 µg/$494

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Human MALIN / NHLRC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93057

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.1 kDa

Price:

20 µg/$150

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