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MAGEA4

melanoma antigen family A, 4

MAGEA4 is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. At least four variants encoding the same protein have been found for this gene.

Gene Name: melanoma antigen family A, 4
Synonyms: MAGEA4, MAGE-4 antigen, MAGE-41 antigen, MAGE4A, MAGE-41, Melanoma antigen family A, 4, Cancer/testis antigen 1.4, CT1.4, MAGE-X2, MAGE-X2 antigen, MAGE4, MAGE4B, Melanoma-associated antigen 4
Target Sequences: NM_002362 NP_002353.3 P43358

Publications (1)

1
The expression of the cancer testis antigen MAGE A4: A favorable prognostic biomarker in salivary gland carcinomas related to low tumor grading. Vital D, Ikenberg K, Moch H, Roessle M, Huber GF. Laryngoscope investigative otolaryngology. 2018 April;3:182-190. [Full Text Article] [PubMed:30062133] [PMC:PMC6057220]

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Proteins (17)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (8)
Recombinant (8)
MAGEA4 (17)
No (17)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His, N-Terminal (2)
Myc-DDK (Flag) (11)
Human (13)
293T Cells (4)
E. coli (2)
HEK 293 Cells (9)
Wheat Germ Extract (2)
Purified (2)
MAGEA4 Protein
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E. coli
6His, N-terminus
100 µg/$342; 500 µg/$641; 20 µg/$254
MAGEA4 Protein
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HEK 293 Cells
His, N-Terminal
37 kDa (50 kDa reducing conditions)
10 µg/$289; 200 µg/$646; 50 µg/$360
MAGEA4 Protein - 12.5% SDS-PAGE of human MAGEA4 stained with Coomassie Blue
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Wheat Germ Extract
GST
61.3 kDa
10 µg/$479; 25 µg/$670
MAGEA4 Protein
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E. coli
His, N-Terminal
~35 kDa (50 kDa reducing conditions)
10 µg/$265; 100 µg/$365; 50 µg/$315
MAGEA4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MAGEA4 Protein - Purified recombinant protein MAGEA4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$1,107
MAGEA4 Protein - Purified recombinant protein MAGEA4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$1,107
MAGEA4 Protein - Purified recombinant protein MAGEA4 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$1,107
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HEK 293 Cells
6His, N-terminus
50 kDa
200 µl/$283
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293T Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$150
MAGEA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$150
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293T Cells
Myc-DDK (Flag)
34.7 kDa
20 µg/$150
MAGEA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
100 µg/$494
MAGEA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
100 µg/$494
MAGEA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
100 µg/$494
MAGEA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
34.7 kDa
100 µg/$494
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).