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Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate.
Gene Name: | MAD2 mitotic arrest deficient-like 1 (yeast) |
Synonyms: | MAD2L1, HSMAD2, MAD2, MAD2-like protein 1 |
Target Sequences: | NM_002358 NP_002349.1 Q13257 |
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