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M6PR

mannose-6-phosphate receptor (cation dependent)

Targeting of newly synthesized lysosomal enzymes in many cell types depends on formation of mannose 6-phosphate residues on lysosomal enzymes and recognition of these residues by specific receptors. The cation-dependent mannose 6-phosphate receptor is one of the two transmembrane proteins involved in transport of lysosomal enzymes. Binding of ligands to this receptor is dependent on divalent cations and pH. This receptor is used for intracellular targeting but not for endocytosis of lysosomal enzymes. It is composed of two identical subunits.

Gene Name: mannose-6-phosphate receptor (cation dependent)
Synonyms: M6PR, CD-MPR, SMPR, MPR46, MPRD, Mr 46,000 Man6PR, CD Man-6-P receptor, MPR 46, MPR-46
Target Sequences: NM_002355 NP_002346.1 P20645

Publications (1)

1
Post-Golgi carriers, not lysosomes, confer lysosomal properties to pre-degradative organelles in normal and dystrophic axons. Pearl P Y Lie, Dun-Sheng Yang, Philip Stavrides, Chris N Goulbourne, Ping Zheng, Panaiyur S Mohan, Anne M Cataldo, Ralph A Nixon. Cell reports. 2021 Apr;35:109034. [Full Text Article] [PubMed:33910020] [PMC:PMC8135226] Related Antibodies: LS-C94323.

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Products
Antibodies (19)
Primary (19)
M6PR (19)
Human (17)
Mouse (11)
Rat (8)
Bat (1)
Chimpanzee (3)
Dog (5)
Gibbon (3)
Guinea pig (3)
Horse (1)
Monkey (3)
Pig (4)
Rabbit (3)
IHC (5)
IHC-P (2)
WB (18)
Flo (1)
ELISA (5)
IF (1)
Peptide-ELISA (2)
rabbit (15)
mouse (2)
goat (1)
sheep (1)
Product Group
IHCPlus (2)
IgG (13)
IgG1 (2)
monoclonal mc (2)
polyclonal pc (17)
OTI2F3 (2)
Biotin Conjugated (2)
Carrier-free (1)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (13)
aa51-100 (4)
Internal (2)
aa27-185 (2)
aa123-136 (1)
aa230-260 (1)
aa35-63 (1)
No (18)
Yes (1)
M6PR Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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M6PR Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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M6PR Sheep anti-Mouse Polyclonal (Internal) Antibody
Mouse, Rat
IHC, WB
Unconjugated
500 µg/$393
M6PR Antibody - Jurkat cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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M6PR Rabbit anti-Human Polyclonal (aa51-100) Antibody
Human
WB
Unconjugated
100 µl/$397
M6PR Antibody - Jurkat cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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M6PR Rabbit anti-Human Polyclonal (aa51-100) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Gibbon, Chimpanzee, Human
WB
HRP Conjugated
100 µl/$442
M6PR Antibody - Jurkat cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
M6PR Rabbit anti-Human Polyclonal (aa51-100) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Gibbon, Chimpanzee, Human
WB
Biotin Conjugated
100 µl/$442
M6PR Antibody - Jurkat cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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M6PR Rabbit anti-Human Polyclonal (aa51-100) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Gibbon, Chimpanzee, Human
WB
FITC Conjugated
100 µl/$442
M6PR Antibody - M6PR Antibody western blot of A549 cell line lysates (35 ug/lane). The M6PR antibody detected the M6PR protein (arrow).
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M6PR Rabbit anti-Human Polyclonal (aa230-260) Antibody
Human
Flo, IF, WB
Unconjugated
400 µl/$393
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M6PR Goat anti-Human Polyclonal (aa123-136) Antibody
Rat, Pig, Horse, Bat, Mouse, Human, Monkey
Peptide-ELISA
Unconjugated
100 µg/$467
M6PR Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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M6PR Rabbit anti-Human Polyclonal (aa35-63) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
Select
M6PR Rabbit anti-Mouse Polyclonal (Internal) Antibody
Mouse, Rat
IHC, WB
Unconjugated
500 µg/$393
M6PR Antibody - Immunohistochemistry of paraffin-embedded human testis tissue using M6PR Antibody at dilution of 1:100
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M6PR Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
Select
M6PR Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Select
M6PR Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
Select
M6PR Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
Select
M6PR Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
M6PR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
M6PR Antibody - Western blot analysis of M6PR using mouse brain lysates
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M6PR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
M6PR Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY M6PR. (Right lane) cDNA for 48 hrs and lysed
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M6PR Mouse anti-Human Monoclonal (aa27-185) (OTI2F3) Antibody
Dog, Human, Monkey
WB
Unconjugated
100 µl/$434
M6PR Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY M6PR. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-M6PR. (1:500)
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M6PR Mouse anti-Human Monoclonal (aa27-185) (Carrier-free) (OTI2F3) Antibody
Dog, Human, Monkey
WB
Unconjugated, Carrier-free
100 µg/$511
Viewing 1-19 of 19 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).