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Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Name: | lymphotoxin beta (TNF superfamily, member 3) |
Family/Subfamily: | TNF , not assigned-TNF |
Synonyms: | LTB, LT-beta, p33, LTbeta, Lymphotoxin-beta, Tumor necrosis factor C, TNF-C, TNFSF3, TNFC |
Target Sequences: | NM_002341 NP_002332.1 Q06643 |
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