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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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LY96 / MD2 / MD-2
lymphocyte antigen 96
MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e. g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
| Gene Name: | lymphocyte antigen 96 |
| Synonyms: | LY96, ESOP1, ESOP-1, Lymphocyte antigen 96, Ly-96, Protein MD-2, MD-2, MD2 |
| Target Sequences: | NM_015364 NP_056179.3 Q9Y6Y9 |
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